产品详情
简单介绍：
重组鼠白细胞介素-36α，153a.a.蛋白与其它公司提供的重组蛋白不同，rMuIL-36α, 153a.a.蛋白产品为采用CFS的无细胞麦胚蛋白合成系统表达出来的重组蛋白，可表达出对细胞有毒性、易被蛋白酶降解的蛋白；并获得具有良好的可溶性，并有翻译后修饰、从而部分具有功能的蛋白.同时独有的全自动蛋白纯化技术则简便高效，将蛋白纯化过程中对蛋白的损伤降低到*小程度.重组鼠白细胞介素-36α，153a.a.蛋白（全长序列）产品可用于Western Blot验证、抗体制备、蛋白检测、ELISA等试验中.
详情介绍：
重组鼠白细胞介素-36α，153a.a.蛋白
| Synonyms | FIL1 epsilon, IL-1 epsilon, IL-1F6, IL-1H1 |
| Species | 重组鼠白细胞介素-36α，153a.a.蛋白Murine |
| Accession | Q9JLA2 |
| GeneID | 54448 |
| SDS-PAGE |  |
| Reference | 重组鼠白细胞介素-36α，153a.a.蛋白1. Nicklin MJ, Barton JL, Nguyen M, et al. 2002. Genomics. 79:718-25. 2. Dinarello C, Arend W, Sims J, et al. 2010. Nat Immunol. 11:973. 3. Barksby HE, Lea SR, Preshaw PM, et al. 2007. Clin Exp Immunol. 149:217-25. 4. Smith DE, Renshaw BR, Ketchem RR, et al. 2000. J Biol Chem. 275:1169-75. 5. Dunn E, Sims JE, Nicklin MJ, et al. 2001. Trends Immunol. 22:533-6. |
| Background | 重组鼠白细胞介素-36α，153a.a.蛋白Interleukin-36 (IL-36) is a pro-inflammatory cytokine which plays an important role in the pathophysiology of several diseases. IL-36α, IL-36β, and IL-36γ (formerly IL-1F6, IL-1F8, and IL-1F9) are IL-1 family members that signal through the IL-1 receptor family members IL-1Rrp2 (IL-1RL2) and IL-1RAcP. IL-36α is mainly found in skin and lymphoid tissues, but also in fetal brain, trachea, stomach and intestine. It is expressed by monocytes, B and T cells. Notably, IL-36 alpha is the only novel IL-1 family member expressed on T-cells. Recombinant murine interleukin-36 alpha contains 153 amino acids residues which is a single non-glycosylated polypeptide. Specifically,重组鼠白细胞介素-36α，153a.a.蛋白mouse IL-36α shares 83 % a.a. sequence identity with rat IL-36α, 54 – 60 % with human, rabbit, equine and bovine IL-36α. |
