产品详情
简单介绍：
Anti-Phospho-BTK (Tyr551)抗体产品质量稳定，实验效果明显，货期快，价格优惠，欢迎垂询订购！我公司长期供应**组化抗体、WB抗体、**组化试剂盒和抗体试验所需全部相关试剂、荧光标记抗体、单克隆抗体、多克隆抗体、各种标记的二抗IgG/IgM/IgD/IgA等科研实验抗体。Anti-Phospho-BTK (Tyr551)抗体用于**组化实验,WB实验,相应的标记抗体有HRP标记抗体,FITC标记,BIO等。
详情介绍：
Rabbit Anti-Phospho-BTK (Tyr551)
Cat. Number:
Anti-Phospho-BTK (Tyr551)抗体KL-12901R
Quantity size:
0.1ml
Concentration:
1mg/ml Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Background:
Brutons tyrosine kinase (BTK)
Anti-Phospho-BTK (Tyr551)抗体is a member of the BTK/Tec family of cytoplasmic tyrosine kinases. Like other BTK family members, it contains a pleckstrin homology (PH) domain, Src homology SH3 and SH2 domains. BTK plays an important role in B cell development. Activation of B cells by various ligands is accompanied by BTK membrane translocation mediated by its PH domain binding to phosphatidylinositol-3,4,5-trisphosphate. The membrane located BTK is active and associated with transient phosphorylation of two tyrosine residues, Tyr551 and Tyr223. Tyr551 in the activation loop is transphosphorylated by the Src family tyrosine kinase, leading to autophosphorylation at Tyr223 within the SH3 domain, which is necessary for full activation. The activation of BTK is negatively regulated by PKC beta through phosphorylation of BTK at Ser180, which results in reduced membrane recruitment, transphosphorylation and subsequent activation. The PKC/BTK inhibitory signal is likely to be a key determinant of the B cell receptor signaling threshold to
Anti-Phospho-BTK (Tyr551)抗体maintain optimal BTK activity.
Also known as:
BTK (Phospho-Tyr551); BTK (phospho Y551); p-BTK (phospho Y551); Agammaglobulinaemia tyrosine kinase; AGMX 1; AGMX1; AT; ATK; B cell progenitor kinase; B-cell progenitor kinase; BPK; Bruton agammaglobulinemia
Anti-Phospho-BTK (Tyr551)抗体tyrosine kinase; Bruton tyrosine kinase; Bruton’s Tyrosine Kinase; Btk; BTK_HUMAN; IMD 1; IMD1; MGC126261; MGC126262; OTTHUMP00000063593; PSCTK 1; PSCTK1; Tyrosine protein kinase BTK; Tyrosine-protein kinase BTK; XLA.
Specificity:
●
Rabbit Polyclonal IgG, affinity purified by Protein A.
●
Reacts with: Human, .
●
Immunogen: KLH conjugated Synthesised phosphopeptide derived from human Btk around the phosphorylation site of Tyr551 [DE(p-Y)TS].
●
Predicted Molecular Weight: 76kDa.
Storage:
Shipped at 4℃, Store at -20℃
Anti-Phospho-BTK (Tyr551)抗体(Avoid repeated freeze/thaw cycles).
Application:
WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
Not yet tested in other applications.
Optimal working dilutions must be determined by the end user.
Not yet tested in other applications.
Optimal working dilutions must be determined by the end user.
kl964Mu01 钙蛋白酶1(CAPN1)多克隆抗体 Polyclonal Antibody to Calpain 1, Large Subunit (CAPN1)
kl966Hu01 多配体蛋白聚糖1(SDC1)多克隆抗体 Polyclonal Antibody to Syndecan 1 (SDC1)
kl966Mu01 多配体蛋白聚糖1(SDC1)多克隆抗体 Polyclonal Antibody to Syndecan 1 (SDC1)
kl966Ra01 多配体蛋白聚糖1(SDC1)多克隆抗体 Polyclonal Antibody to Syndecan 1 (SDC1)
kl967Hu01 载脂蛋白A4(APOA4)多克隆抗体 Polyclonal Antibody to Apolipoprotein A4 (APOA4)
kl967Mu01 载脂蛋白A4(APOA4)多克隆抗体 Polyclonal Antibody to Apolipoprotein A4 (APOA4)
kl967Po01 载脂蛋白A4(APOA4)多克隆抗体 Polyclonal Antibody to Apolipoprotein A4 (APOA4)
kl968Hu01 载脂蛋白D(APOD)多克隆抗体 Polyclonal Antibody to Apolipoprotein D (APOD)
kl969Mu01 补体成分5(C5)多克隆抗体 Polyclonal Antibody to Complement Component 5 (C5)
kl969Ra01 补体成分5(C5)多克隆抗体 Polyclonal Antibody to Complement Component 5 (C5)
kl970Hu01 补体成分8γ(C8γ)多克隆抗体 Polyclonal Antibody to Complement Component 8g (C8g)
kl971Hu01 蛋白S(PROS)多克隆抗体 Polyclonal Antibody to Protein S (PROS)
kl972Hu01 色素上皮衍生因子(PEDF)多克隆抗体 Polyclonal Antibody to Pigment Epithelium Derived Factor (PEDF)
kl972Mu01 色素上皮衍生因子(PEDF)多克隆抗体 Polyclonal Antibody to Pigment Epithelium Derived Factor (PEDF)
kl973Hu01 血小板反应蛋白解整合素金属肽酶1(ADAMTS1)多克隆抗体 Polyclonal Antibody to A Disintegrin And Metalloproteinase With Thrombospondin 1 (ADAMTS1)
kl973Ra01 血小板反应蛋白解整合素金属肽酶1(ADAMTS1)多克隆抗体 Polyclonal Antibody to A Disintegrin And Metalloproteinase With Thrombospondin 1 (ADAMTS1)
kl974Hu01 血小板反应蛋白解整合素金属肽酶7(ADAMTS7)多克隆抗体 Polyclonal Antibody to A Disintegrin And Metalloproteinase With Thrombospondin 7 (ADAMTS7)
