产品详情
简单介绍：
Anti-Phospho-Insulin Receptor Beta (Tyr1361)抗体产品质量稳定，实验效果明显，货期快，价格优惠，欢迎垂询订购！我公司长期供应**组化抗体、WB抗体、**组化试剂盒和抗体试验所需全部相关试剂、荧光标记抗体、单克隆抗体、多克隆抗体、各种标记的二抗IgG/IgM/IgD/IgA等科研实验抗体。Anti-Phospho-Insulin Receptor Beta (Tyr1361)抗体用于**组化实验,WB实验,相应的标记抗体有HRP标记抗体,FITC标记,BIO等。
详情介绍：
Rabbit Anti-Phospho-Insulin Receptor Beta (Tyr1361)
Cat. Number:
Anti-Phospho-Insulin Receptor Beta (Tyr1361)抗体KL-3493R
Quantity size:
0.1ml
Concentration:
1mg/ml Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Background:
The human insulin receptor is a heterotetrameric membrane glycoprotein consisting of disulfide linked subunits in a beta-alpha-alpha-beta configuration. The beta subunit (95 kDa) possesses a single transmembrane domain, whereas the alpha subunit (135 kDa) is completely extracellular. The insulin receptor exhibits receptor
Anti-Phospho-Insulin Receptor Beta (Tyr1361)抗体tyrosine kinase (RTK) activity. RTKs are single pass transmembrane receptors that possess intrinsic cytoplasmic enzymatic activity, catalyzing the transfer of the gamma phosphate of ATP to tyrosine residues in protein substrates. RTKs are essential components of signal transduction pathways that affect cell proliferation, differentiation, migration and metabolism.
Included in this large protein family are the insulin receptor and the receptors for growth factors such as epidermal growth factor, fibroblast growth factor and vascular endothelial growth factor. Receptor activation occurs through ligand binding, which facilitates receptor dimerization and autophosphorylation of specific tyrosine residues in the cytoplasmic portion. The interaction of insulin with the alpha subunit of the insulin receptor activates the protein tyrosine kinase of the beta subunit, which then undergoes an autophosphorylation that increases its tyrosine kinase activity. Three adapter proteins, IRS1, IRS2 and Shc, become phosphorylated on tyrosine residues following insulin receptor activation. These three phosphorylated proteins then interact with SH2 domain containing signaling proteins.
Included in this large protein family are the insulin receptor and the receptors for growth factors such as epidermal growth factor, fibroblast growth factor and vascular endothelial growth factor. Receptor activation occurs through ligand binding, which facilitates receptor dimerization and autophosphorylation of specific tyrosine residues in the cytoplasmic portion. The interaction of insulin with the alpha subunit of the insulin receptor activates the protein tyrosine kinase of the beta subunit, which then undergoes an autophosphorylation that increases its tyrosine kinase activity. Three adapter proteins, IRS1, IRS2 and Shc, become phosphorylated on tyrosine residues following insulin receptor activation. These three phosphorylated proteins then interact with SH2 domain containing signaling proteins.
Also known as:
Insulin Receptor (phospho Y1361); Insulin
Anti-Phospho-Insulin Receptor Beta (Tyr1361)抗体Receptor (phospho Try1361); CD 220; CD220; CD220 antigen; HHF 5; HHF5; HIR B; INSR; INSR; Insulin receptor; Insulin receptor subunit beta; IR; INSR_HUMAN.
Specificity:
●
Rabbit Polyclonal IgG, affinity purified by Protein A.
●
Reacts with: Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep, .
●
Immunogen: KLH conjugated Synthesised phosphopeptide derived from human.
●
Predicted Molecular Weight: 68kDa.
Anti-Phospho-Insulin Receptor Beta (Tyr1361)抗体
Storage:
Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).
Application:
WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:50-500 IF=1:100-500
Not yet tested in other applications. Anti-Phospho-Insulin Receptor Beta (Tyr1361)抗体
Optimal working dilutions must be determined by the end user.
Not yet tested in other applications. Anti-Phospho-Insulin Receptor Beta (Tyr1361)抗体
Optimal working dilutions must be determined by the end user.
kl446Mu02 抑制素βC(INHβC)多克隆抗体 Polyclonal Antibody to Inhibin Beta C (INHbC)
kl448Gu01 胰岛素(INS)多克隆抗体 Polyclonal Antibody to Insulin (INS)
kl448Mu02 胰岛素(INS)多克隆抗体 Polyclonal Antibody to Insulin (INS)
kl449Mu02 胱天蛋白酶7(CASP7)多克隆抗体 Polyclonal Antibody to Caskle 7 (CASP7)
kl451Mu02 激肽释放酶5(KLK5)多克隆抗体 Polyclonal Antibody to Kallikrein 5 (KLK5)
kl469Mu02 内皮脂肪酶(LIPG)多克隆抗体 Polyclonal Antibody to Likle, Endothelial (LIPG)
kl471Ga01 骨钙素(OC)多克隆抗体 Polyclonal Antibody to Osteocalcin (OC)
kl471Mu02 骨钙素(OC)多克隆抗体 Polyclonal Antibody to Osteocalcin (OC)
kl472Mu02 降钙素(CT)多克隆抗体 Polyclonal Antibody to Calcitonin (CT)
kl473Mu02 C组着色性干皮病偶联因子(XPC)多克隆抗体 Polyclonal Antibody to Xeroderma Pigmentosum, Complementation Group C (XPC)
kl475Mu02 维生素D受体(VDR)多克隆抗体 Polyclonal Antibody to Vitamin D Receptor (VDR)
kl475Ra01 维生素D受体(VDR)多克隆抗体 Polyclonal Antibody to Vitamin D Receptor (VDR)
kl476Mu02 半胱氨酸蛋白酶抑制剂A(CSTA)多克隆抗体 Polyclonal Antibody to Cystatin A (CSTA)
kl478Mu02 心肌肌钙蛋白I(TNNI3)多克隆抗体 Polyclonal Antibody to Troponin I Type 3, Cardiac (TNNI3)
kl480Mu02 肌红蛋白(MYO)多克隆抗体 Polyclonal Antibody to Myoglobin (MYO)
