产品详情
简单介绍：
Anti-BRLF1抗体产品质量稳定，实验效果明显，货期快，价格优惠，欢迎垂询订购！我公司长期供应**组化抗体、WB抗体、**组化试剂盒和抗体试验所需全部相关试剂、荧光标记抗体、单克隆抗体、多克隆抗体、各种标记的二抗IgG/IgM/IgD/IgA等科研实验抗体。Anti-BRLF1抗体用于**组化实验,WB实验,相应的标记抗体有HRP标记抗体,FITC标记,BIO等。
详情介绍：
Rabbit Anti-BRLF1
Cat. Number:
Anti-BRLF1抗体KL-4542R
Quantity size:
0.2ml
Concentration:
1mg/ml Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Background:
Expression of the Epstein-Barr
Anti-BRLF1抗体virus (EBV) immediate-early (IE) protein BRLF1 induces the lytic form of viral replication in most EBV-positive cell lines. BRLF1 is a transcriptional activator that binds directly to a GC-rich motif present in some EBV lytic gene promoters. However, BRLF1 activates transcription of the other IE protein, BZLF1, through an indirect mechanism which we previously showed to require activation of the stress mitogen-activated protein kinases. Here we demonstrate that BRLF1 activates phosphatidylinositol-3 (PI3) kinase signaling in host cells. We show that the specific PI3 kinase inhibitor, LY294002, completely abrogates the ability of a BRLF1 adenovirus vector to induce the lytic form of EBV infection, while not affecting lytic infection induced by a BZLF1 adenovirus vector.
Anti-BRLF1抗体Furthermore, we demonstrate that the requirement for PI3 kinase activation in BRLF1-induced transcriptional activation is promoter dependent. BRLF1 activation of the SM early promoter (which occurs through a direct binding mechanism) does not require PI3 kinase activation, whereas activation of the IE BZLF1 and early BMRF1 promoters requires PI3 kinase activation. Thus, there are clearly two separate mechanisms by which BRLF1 induces transcriptional activation.
Also known as:
Replication and transcription
Anti-BRLF1抗体activator; Rta; Immediate-early protein Rta; HHV4tp2_gp33; BRLF1 [Human herpesvirus 4 type 2].
Specificity:
●
Rabbit Polyclonal IgG, affinity purified by Protein A.
●
Reacts with: HHV4tp2.
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Immunogen: KLH conjugated synthetic peptide derived from human herpesvirus 4 type 2 BRLF1.
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Predicted Molecular Weight: 66.5kDa.
Storage:
Shipped at 4℃,
Anti-BRLF1抗体Store at -20℃ (Avoid repeated freeze/thaw cycles).
Application:
WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
Not yet tested in other applications.
Optimal working dilutions Anti-BRLF1抗体must be determined by the end user.
Not yet tested in other applications.
Optimal working dilutions Anti-BRLF1抗体must be determined by the end user.
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kl050Si01 胰岛素样生长因子1(IGF1)多克隆抗体 Polyclonal Antibody to Insulin Like Growth Factor 1 (IGF1)
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kl074Mu01 **球蛋白G1(IgG1)多克隆抗体 Polyclonal Antibody to Immunoglobulin G1 (IgG1)
